منابع مشابه
Protein-mediated enamel mineralization.
Enamel is a hard nanocomposite bioceramic with significant resilience that protects the mammalian tooth from external physical and chemical damages. The remarkable mechanical properties of enamel are associated with its hierarchical structural organization and its thorough connection with underlying dentin. This dynamic mineralizing system offers scientists a wealth of information that allows t...
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BACKGROUND Management of human teeth has moved from a surgical to a more conservative approach of inhibiting or preventing lesion progression. Increasing enamel mineralization is crucial in this regard. A potential difficulty is the preferential mineralization of the outermost portion of the enamel that can prevent overall mineralization. We describe a strategy for increasing the mineralization...
متن کاملThe Pattern of the Mineralization of Enamel
Voluminous literature on the subject of enamel mineralization has been reviewed and published recently.1. 2 Therefore, the author will not attempt to cite again the numerous individual contributions of the many investigators in this area. An evaluation of the past studies leads the reader to the conclusion that at least two general concepts of enamel mineralization have been developed and appea...
متن کاملTGF-ß Regulates Enamel Mineralization and Maturation through KLK4 Expression
Transforming growth factor-ß (TGF-ß) signaling plays an important role in regulating crucial biological processes such as cell proliferation, differentiation, apoptosis, and extracellular matrix remodeling. Many of these processes are also an integral part of amelogenesis. In order to delineate a precise role of TGF-ß signaling during amelogenesis, we developed a transgenic mouse line that harb...
متن کاملAmyloid-like ribbons of amelogenins in enamel mineralization
Enamel, the outermost layer of teeth, is an acellular mineralized tissue that cannot regenerate; the mature tissue is composed of high aspect ratio apatite nanocrystals organized into rods and inter-rod regions. Amelogenin constitutes 90% of the protein matrix in developing enamel and plays a central role in guiding the hierarchical organization of apatite crystals observed in mature enamel. To...
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ژورنال
عنوان ژورنال: Frontiers in Bioscience
سال: 2012
ISSN: 1093-9946,1093-4715
DOI: 10.2741/4034